運動科学研究室 Sports Science Division
競走能力をパワーアップする！
運動科学研究室では、心臓や肺などの酸素運搬能力や筋肉のトレーニング適応に関する研究、走行フォームや筋活動などを解析するバイオメカニクスに関する研究、糖やアミノ酸の代謝など栄養に関する研究を行っています。これらの分野の研究を総合的に行うことで、競走馬が速く走ることができる仕組みについて明らかにし、科学的に裏付けられたトレーニング法、飼料給与法、怪我や熱中症を起こす要因や予防法などについて提言しています。
The Sports Science Division focuses on cardiovascular and skeletal muscle physiology, biomechanics on locomotion and muscle activity, and nutrition on carbohydrate and amino acid metabolism in horses. Our purpose is to clarify the mechanism on equine athletic performance through the integrative studies on exercise physiology and biomechanics, and we have made scientific evidence-based suggestions on training, nutrition, and risk factors for musculoskeletal disorders and exertional heat illness.
研究スタッフ Members
- 室長Manager向井 和隆Kazutaka MUKAI, DVM, PhD
- 主査Researcher高橋 佑治Yuji TAKAHASHI, DVM, PhD
- 主査Researcher胡田 悠作Yusaku EBISUDA, DVM, PhD
- 主査Researcher杉山 史Fumi SUGIYAMA, DVM
研究課題 Research project
原著論文 Publications
2024
Takahashi Y, Niwa H, Ebisuda Y, Mukai K, Yoshida T, Raidal S, Padalino B, Ohmura H
Increased freedom of head movement mitigates stress and bacterial load in the airways of horses during transport
Front Vet Sci 11, 1477653, 2024 [PubMed]
Takahashi K, Mukai K, Ebisuda Y, Sugiyama F, Yoshida T, Hatta H, Kitaoka Y
Effects of pacing strategy on metabolic responses to 2-min intense exercise in Thoroughbred horses
Sci Rep 14, 18352, 2024 [PubMed]
Landsbergen K, Davis BL, Garcia K, Kenny O, Kernot N, Scott WM, Sparks H, Takahashi Y, Toth K, Pfau T
Movement symmetry and back range of motion in reining quarter horses
J Equine Rehabil 2, 100011, 2024
Takahashi Y, Takahashi T, Mukai K, Ebisuda Y, Ohmura H
Changes in muscle activation with graded surfaces during canter in Thoroughbred horses on a treadmill
PLoS One 19, e0305622, 2024 [PubMed]
Ebisuda Y, Mukai K, Takahashi Y, Yoshida T, Matsuhashi T, Kawano A, Miyata H, Kuwahara M, Ohmura H
Heat acclimation improves exercise performance in hot conditions and increases heat shock protein 70 and 90 of skeletal muscles in Thoroughbred horses
Physiol Rep 12, e16083, 2024 [PubMed]
Massie S, Bayly W, Ohmura H, Takahashi Y, Mukai K, Léguillette R
Field-training in young two-year-old thoroughbreds: investigating cardiorespiratory adaptations and the presence of exercise induced pulmonary hemorrhage
BMC Vet Res 20, 159, 2024 [PubMed]
Koshyk A, Pohl AJ, Takahashi Y, Scott WM, Sparks HD, Edwards WB
Influence of microarchitecture on stressed volume and mechanical fatigue behaviour of equine subchondral bone
Bone 182, 117054, 2024 [PubMed]
Takahashi K, Mukai K, Takahashi Y, Ebisuda Y, Hatta H, Kitaoka Y
Metabolomic responses to high-intensity interval exercise in equine skeletal muscle: effects of rest interval duration
J Exp Biol 227, 246896, 2024 [PubMed]
Marlin DJ, Reynolds H, Mukai K, Neil K, Akerstrom G
Estimating rectal temperature in exercising horses in a competition environment using infrared thermal imaging
Comp Exerc Physiol 20, 45-53, 2024
2023
Mukai K, Ohmura H, Takahashi Y, Ebisuda Y, Yoneda K, Miyata H
Physiological and skeletal muscle responses to high-intensity interval exercise in Thoroughbred horses
Front Vet Sci 10, 1241266, 2023 [PubMed]
Ohnuma A, Tozaki T, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Takahashi Y, Nagata SI
Multiplex detection of transgenes using πcode technology for gene doping control
Anal Chem 95, 10149-10154, 2023 [PubMed]
Pfau T, Landsbergen K, Davis BL, Kenny O, Kernot N, Rochard N, Porte-Proust M, Sparks H, Takahashi Y, Toth K, Scott WM
Comparing inertial measurement units to markerless video analysis for movement symmetry in quarter horses
Sensors (Basel) 23, 8414, 2023 [PubMed]
Ebisuda Y, Mukai K, Takahashi Y, Yoshida T, Kawano A, Matsuhashi T, Miyata H, Kuwahara M, Ohmura H
Acute exercise in a hot environment increases heat shock protein 70 and peroxisome proliferator-activated receptor γ coactivator 1α mRNA in Thoroughbred horse skeletal muscle
Front Vet Sci 10, 1230212, 2023 [PubMed]
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Takahashi Y, Nagata SI
Investigation of optimal procedures for storage and use of plasma samples suitable for gene doping tests
J Equine Sci 34, 21-27, 2023 [PubMed]
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Takahashi Y, Nagata SI
Short Insertion and deletion discoveries via whole-genome sequencing of 101 Thoroughbred racehorses
Genes (Basel) 14, 638, 2023 [PubMed]
Takahashi Y, Takahashi T, Mukai K, Ebisuda Y, Ohmura H
Effect of speed and leading or trailing limbs on surface muscle activities during canter in Thoroughbred horses
PLoS One 18, e0286409, 2023 [PubMed]
Sugiyama F, Takahashi Y, Nomura M, Ebisuda Y, Mukai K, Yoshida T
Risk factors for epistaxis in Thoroughbred flat races in Japan (2001-2020)
Animals 13, 1348, 2023 [PubMed]
Ebisuda Y, Mukai K, Takahashi Y, Ohmura H
Effect of high ambient temperature on physiological responses during incremental exercise in Thoroughbred horses
Comp Exer Physiol 19, 159-167, 2023
2022
Takahashi Y, Yoshihara E, Takahashi T
Comparison of heel movement between two different glue-on type shoes and nailed shoes in Thoroughbreds
J Equine Vet Sci 113, 103939, 2022 [PubMed]
Kitaoka Y, Mukai K, Tonai S, Ohmura H, Takahashi T
Effect of post-exercise muscle cooling on PGC-1α and VEGF mRNA expression in Thoroughbreds
Comp Exer Physiol 18, 21-25, 2022
Mizobe F, Takahashi Y, Kusano K
Risk factors for jockey falls in Japanese Thoroughbred jump racing
J Equine Vet Sci 109, 103822, 2022 [PubMed ]
2021
Mukai K, Kitaoka Y, Takahashi Y, Takahashi T, Takahashi K, Ohmura H.
Moderate-intensity training in hypoxia improves exercise performance and glycolytic capacity of skeletal muscle in horses.
Physiol Rep 9, e15145, 2021 [PubMed]
Mizobe F, Takahashi Y, Kusano K
Risk factors for jockey falls in Japanese Thoroughbred flat racing
J Equine Vet Sci 106, 103749, 2021 [PubMed]
Ohmura H, Mukai K, Takahashi Y, Takahashi T
Metabolomic analysis of skeletal muscle before and after strenuous exercise to fatigue
Sci Rep 11, 11261, 2021 [PubMed]
Takahashi Y, Mukai K, Ohmura H, Takahashi T
Changes in muscle activity with exercise-induced fatigue in Thoroughbred horses
Comp Exer Physiol 17, 25-34, 2021
Takahashi Y, Takahashi T, Mukai K, Ohmura H
Effects of fatigue on stride parameters in Thoroughbred racehorses during races
J Equine Vet Sci 101, 103447, 2021 [PubMed]
Mukai K, Ohmura H, Takahashi Y, Kitaoka Y, Takahashi T
Four weeks of high-intensity training in moderate, but not mild hypoxia improves performance and running economy more than normoxic training in horses
Physiol Rep 9, e14760, 2021 [PubMed]
2020
Ohmura H, Mukai K, Matsui A, Takahashi T, Jones JH
Cardiopulmonary function during supramaximal exercise in hypoxia, normoxia and hyperoxia in Thoroughbred horses
J Equine Sci 31, 67-73, 2020 [PubMed]
Mizobe F, Takahashi Y, Kusano K
Epidemiology of jockey falls and injuries in flat and jump races in Japan (2003–2017)
J Equine Sci 31, 101-104, 2020 [PubMed]
Kitaoka Y, Mukai K, Takahashi K, Ohmura H, Hatta H
Effect of lactate administration on exercise-induced PGC-1α mRNA expression in Thoroughbreds
Comp Exer Physiol 16, 253-258, 2020
Takahashi Y, Ohmura H, Mukai K, Shiose T, Takahashi T
A comparison of five cooling methods in hot and humid environments in Thoroughbred horses
J Equine Vet Sci 91, 103130, 2020 [PubMed]
Wang W, Mukai K, Takahashi K, Ohmura H, Takahashi T, Hatta H, Kitaoka Y
Short-term hypoxic training increases monocarboxylate transporter 4 and phosphofructokinase activity in Thoroughbreds
Physiol Rep 8, e14473, 2020 [PubMed]
Mukai K, Ohmura H, Matsui A, Aida H, Takahashi T, Jones JH
High-intensity training in normobaric hypoxia enhances exercise performance and aerobic capacity in Thoroughbred horses: a randomized crossover study
Physiol Rep 8, e14442, 2020 [PubMed]
Takahashi Y, Takahashi T
Risk factors for exertional heat illness in Thoroughbred racehorses in flat races in Japan (2005-2016)
Equine Vet J 52, 364-368, 2020 [PubMed]
Takahashi Y, Mukai K, Ohmura H, Takahashi T
Do muscle activities of M. splenius and M. brachiocephalicus decrease because of exercise-induced fatigue in Thoroughbred horses?
J Equine Vet Sci 86, 102901, 2020 [PubMed]
2019
Gerling CJ, Mukai K, Chabowski A, Heigenhauser GJF, Holloway GP, Spriet LL, Jannas-Vela S
Incorporation of omega-3 fatty acids into human skeletal muscle sarcolemmal and mitochondrial membranes following 12 weeks of fish oil supplementation
Front Physiol 10, 348, 2019 [PubMed]
Birks EK, Ohmura H, Jones JH
Measuring VO2 in hypoxic and hyperoxic conditions using dynamic gas mixing with a flow-through indirect calorimeter
J Equine Sci 30, 87-92, 2019 [PubMed]
2018
Takahashi Y, Ishikawa Y, Ohmura H
Treatment of recent-onset atrial fibrillation with quinidine and flecainide in Thoroughbred racehorses; 107 cases (1987-2014)
J Am Vet Med Assoc 252, 1409-1414, 2018 [PubMed]
Takahashi Y, Mukai K, Matsui A, Ohmura H, Takahashi T
Electromyographic changes in hind limbs of Thoroughbreds with fatigue induced by treadmill exercise
Am J Vet Res 79, 828-835, 2018 [PubMed]
2017
Mukai K, Hiraga A, Takahashi T, Matsui A, Ohmura H, Aida H, Jones JH
Effects of maintaining different exercise intensities during detraining on aerobic capacity in Thoroughbreds
Am J Vet Res 78, 215-222, 2017 [PubMed]
Okabe K, Mukai K, Ohmura H, Takahashi T, Miyata H
Effect of acute high-intensity exercise in normobaric hypoxia on Thoroughbred skeletal muscle
J Sports Med Phys Fitness 57, 711-719, 2017 [PubMed]
Ohmura H, Mukai K, Takahashi Y, Takahashi T, Jones JH
Hypoxic training increases maximal oxygen consumption in Thoroughbred horses well-trained in normoxia
J Equine Sci 28, 41-45, 2017 [PubMed]
Ohmura H, Mukai K, Takahashi T, Aida H, Jones JH
Cardiorespiratory function in Thoroughbreds during locomotion on a treadmill at an incline or decline
Am J Vet Res 78, 340-349, 2017 [PubMed]
Takahashi Y, Takahashi T
Seasonal fluctuations in body weight during growth of Thoroughbred racehorses during their athletic career
BMC Vet Res 13, 257, 2017 [PubMed]
Ohmura H, Jones JH
Changes in heart rate and heart rate variability as a function of age in Thoroughbred horses
J Equine Sci 28, 99-103, 2017 [PubMed]
松本拓也・太田 憲・仰木裕嗣・高橋敏之・間 弘子・湯川治敏
走行するサラブレッドの遊脚期における振動数の調整
バイオメカニズム学会誌 41, 91-97, 2017
2016
Ohmura H, Okano A, Mukai K, Fukuda K, Takahashi T
Cardiorespiratory and anesthetic effects of combined alfaxalone, butorphanol, and medetomidine in Thoroughbred horses
J Equine Sci 27, 7-11, 2016 [PubMed]
Nagahisa H, Mukai K, Ohmura H, Takahashi T, Miyata H
Effect of high-intensity training in normobaric hypoxia on Thoroughbred skeletal muscle
Oxid Med Cell Longev 1535367, 2016 [PubMed]
Tozaki T, Kikuchi M, Kakoi H, Hirota K, Mukai K, Aida H, Nakamura S, Nagata S
Profiling of exercise-induced transcripts in the peripheral blood cells of Thoroughbred horses
J Equine Sci 27, 157-164, 2016 [PubMed]
2015
Takahashi T
The effect of age on the racing speed of Thoroughbred racehorses
J Equine Sci 26, 43-48, 2015 [PubMed]
Takahashi Y, Akai M, Murase H, Nambo Y
Seasonal changes in serum progesterone levels in Thoroughbred racehorses in training
J Equine Sci 26, 135-139, 2015 [PubMed]
学会発表 Conference presantation
2023
Sugiyama F, Takahashi Y, Ebisuda Y, Mukai K, Yoshida T
Comparison of muscle activity during trotting on different surface types
International Cenference on Canine and Equine Locomotion (ICEL9) 2023.8
Takahashi Y, Takahashi T, Mukai K, Ebisuda Y, Ohmura H
Effects of incline on muscle activity of hindlimb during canter on a treadmill
International Cenference on Canine and Equine Locomotion (ICEL9) 2023.8
Ebisuda Y, Mukai K, Takahashi Y, Yoshida T, Kawano A, Matsuhashi T, Miyata H, Ohmura H
Effects of heat acclimation in Thoroughbred skeletal muscle
28th Annual Congress of the European College of Sports Science 2023.7
Mukai K, Ebisuda Y, Sugiyama F, Yoshida T, Miyata H
Acute physiological responses to hyperoxichigh-intensity interval exercise in horses
28th Annual Congress of the European College of Sports Science 2023.7
Ebisuda Y, Mukai K, Takahashi Y, Yoshida T, Miyata H, Ohmura H
Adaptation of Thouroubred skeletal muscle after acute exercise in a hot environment
American College of Sports Medicine Annual Meeting (ACSM2023) 2023.5
Mukai K, Takahashi Y, Ebisuda Y, Sugiyama F, Yoshida T, Miyata H
Physiological adaptation to high-intensityinterval training and moderate-intensitycontinuous teaining in horses
American College of Sports Medicine Annual Meeting (ACSM2023) 2023.5
2022
Mukai K, Takahashi Y, Ebisuda Y, Miyata H, Yoshida T
Acute physiological responses to hypoxic high-intensity interval exercise in horses
18th International Biochemistry of Exercise Conference (IBEC) 2022.5
Yoshida T, Takahashi Y, Nomura M, Ebisuda Y, Mukai K
Risk factors of Thoroughbred horses for epistaxis in Japanese flat races
11th International Conference of Equine Exercise Physiology (ICEEP) 2022.6
Mukai K, Takahashi Y, Ebisuda Y, Miyata H, Ohmura H
Acute physiological responses to high-intensity continuous and interval exercise in horses
11th International Conference of Equine Exercise Physiology (ICEEP) 2022.6
Takahashi Y, Takahashi T, Mukai K, Ebisuda Y, Ohmura H
Effect of leading or trailing limbs and speed on equine muscle activity during canter on a treadmill
11th International Conference of Equine Exercise Physiology (ICEEP) 2022.6
Ebisuda Y, Mukai K, Takahashi Y, Yoshida T, Ohmura H
Effects of heat acclimation on physiological adaptations in Thoroughbred horses
11th International Conference of Equine Exercise Physiology (ICEEP) 2022.6
向井和隆
サラブレッドにおける低酸素トレーニングと高強度インターバルトレーニング
第77回日本体力医学会大会シンポジウム 2022.9
向井和隆・高橋佑治・胡田悠作・杉山 史・吉田年伸・宮田浩文
高強度インターバルトレーニングと中強度持続トレーニングに対するサラブレッドのトレーニング適応
日本ウマ科学会第35回学術集会 2022.11
2021
向井和隆・高橋佑治・胡田悠作・宮田浩文・大村 一
高強度インターバル運動に対するサラブレッドの生理的および骨格筋応答
日本ウマ科学会第34回学術集会 2021.12
高橋佑治・大村 一・向井和隆・高橋敏之
駈歩時の運動強度と筋活動の関係
日本ウマ科学会第34回学術集会 2021.12
2020
大村 一
馬の長距離輸送、移動先での競技の難しさ
シンポジウム「馬術競技における獣医師の役割、オリンピックイヤー2020を迎えて」
令和元年度日本獣医師会獣医学術学会年次大会 2020.2
胡田悠作・向井和隆・高橋佑治・大村 一
暑熱環境下における運動前馬体冷却の効果
第163回日本獣医学会学術集会 2020.9
高橋佑治・高橋敏之・向井和隆・大村 一
レース後半の疲労が走行フォームに与える影響
日本ウマ科学会第33回学術集会 2020.11
2019
Ohmura H, Mukai K, Takahashi Y, Takahashi T
Metabolome analysis of skeletal muscle before and after exercise in Thoroughbred horses
24th Annual Congress of the European College of Sport Scinece (ECSS) 2019.7
Mukai K, Ohmura H, Takahashi Y, Kitaoka, Y, Takahashi T
The effects of 2 weeks of high-intensity training in moderate and mild hypoxia on exercise performance and aerobic capacity in horses
24th Annual Congress of the European College of Sport Scinece (ECSS) 2019.7
Takahashi Y, Mukai K, Ohmura H, Takahashi T
Electromyographic changes with exercise-induced fatigue on the treadmill in different muscles
15th International Society for Equitation Science (ISES) Conference 2019.8
大村 一
低酸素下における呼吸循環機能とトレーニング効果に関する研究（学会賞受賞講演）
日本ウマ科学会第32回学術集会 2019.11
2018
Mukai K, Ohmura H, Takahashi Y, Kitaoka Y, Jones JH, Takahashi T
Effects of high-intensity training in moderate and mild hypoxia in horses
American College of Sports Medicine Conference on Integrative Physiology of Exercise (ACSM IPE) 2018.9
Takahashi Y, Mukai K, Ohmura H, Takahashi T
Electromyographic changes in superficial forelimb muscles in fatigued Thoroughbred horses
International Conference on Equine Exercise Physiology (ICEEP) 10 2018.11
Mukai K, Ohmura H, Matsui A, Aida H, Takahashi T, Jones JH
Individual variability in adaptation to normoxic and hypoxic training in Thoroughbred horses
International Conference on Equine Exercise Physiology (ICEEP) 10 2018.11
Ohmura H, Mukai K, Matsui A, Takahashi T, Jones JH
Catecholamine responses to supramaximal hypoxic, normoxic and hyperoxic exercise in horses
International Conference on Equine Exercise Physiology (ICEEP) 10 2018.11
Takahashi T, Nomura M, Maeda T, Toju K, Katsurashima Y, Akai M, Ishikawa Y, Tateno O, Kusano K, Tanabe S, Ohta M, Aida H
Effect of day, age, sex, and trainer ranking on horse training measured with a GPS recorder
International Conference on Equine Exercise Physiology (ICEEP) 10 2018.11
高橋敏之
馬のバイオメカニクスに関する研究（学会賞受賞講演）
日本ウマ科学会第31回学術集会 2018.12
2017
Ohmura H, Mukai K, Takahashi Y, Takahashi T, Jones JH
Metabolomic analysis of skeletal muscle before and 4 hours after normoxic and hypoxic exercise in horses
Cell Symposium on Exercise Metabolism (CELLMET) 2017.5
Mukai K, Ohmura H, Matsui A, Aida H, Jones JH, Takahashi T
Acute high-intensity exercise in hypoxia down-regulates mitochondrial biogenesis in equine skeletal muscle
Cell Symposium on Exercise Metabolism (CELLMET) 2017.5
Ohmura H, Mukai K, Takahashi Y, Takahashi T, Jones JH
Metabolomic analysis of skeletal muscle in horses trained in hypoxia
American College of Sports Medicine (ACSM) 64th Annual Meeting 2017.5
向井和隆・大村 一・高橋佑治・江口諒太・宮田浩文・高橋敏之
GPS調査に基づいた競走馬のトレーニングプログラムがサラブレッドの有酸素能力や骨格筋特性に与える影響
第72回日本体力医学会大会 2017.9
2016
Mukai K, Ohmura H, Matsui A, Takahashi Y, Miyata H, Takahashi T
Are there differences in training protocols and racehorse responses of higher- versus lower-ranked trainers?
Biomedical Basis of Elite Performance 2016 2016.3
Ohmura H, Hiraga A, Jones JH
Effects of initial one-year training on HR, SV, LV mass and HRV in young Thoroughbreds
American College of Sports Medicine 63rd Annual Meeting 2016.6
Takahashi T, Ohmura H, Mukai K, Matsui A, Aida H
Change in force on the superficial digital flexor tendon due to fatigue in Thoroughbred horses
International Canine and Equine Locomotion 8 2016.8
Takahashi Y, Mukai K, Matsui A, Ohmura H, Takahashi T
Electromyographic changes in major hindlimb muscles in fatigued Thoroughbred horses
International Canine and Equine Locomotion 8 2016.8
高橋敏之・高橋佑治
馬体重および日齢と競走成績との関係について
日本ウマ科学会第29回学術集会 2016.11
2015
向井和隆
サラブレッドはなぜ速いのか？
第11回乳酸研究会 2015.2
Mukai K, Ohmura H, Matsui A, Aida H, Takahashi T, Jones JH
Adaptation of equine skeletal muscle mitochondria after high-intensity training in normobaric hypoxia
International Biochemistry of Exercise Conference 2015 2015.9
向井和隆・大村 一・松井 朗・間 弘子・高橋敏之・Jones JH
常圧低酸素下での高強度トレーニングはウマのパフォーマンスと有酸素能力を向上させる
第70回日本体力医学会大会 2015.9
松井 朗・向井和隆・大村 一・高橋敏之・間 弘子
サラブレッドにおける給与飼料の違いが運動中のエネルギー利用に及ぼす影響
日本ウマ科学会第28回学術集会 2015.12
高橋佑治・高橋敏之
牝馬は暑さに強いのか？ －熱中症発症率の性差について－
日本ウマ科学会第28回学術集会 2015.12
大村 一
「跛行に関する運動科学」馬における跛行診断の基本的な考え方・見方について
第91回獣医麻酔外科学会 2015.12